It wouldn't be the first time. As to how good it is may depend on how the conversion to centerfire was done. When I had both a 12/15 and a Cadet, the blocks were interchangeable, but I never did anything with them as I traded the 12/15 off. So a new block is one way. I've heard that by changing the length of the block support arms on the lever you can raise (or lower?) the RF block when closed to a point where the firing pin will strike a CF primer. Seems like the block face and the barrel face might not be in perfect contact but probably close enough. Many a former 22 RF barrel has been used for the Hornet. There's no question on strength of the action, of course.
