Years ago, for a African hunt which never happened, I shot a lot of 375 and 458 in Winchester model 70’s. So much 458 that I developed a flinch that became so bad I had to stop all shooting for over a year. Then it was waiting for me when I returned. Ended up shooting .410 using my left shoulder, for several years. It was five years before I could shoot right handed without flinching, for the most part. I still will flinch once in a few hundred times. At my peak it was three out of four shots. And that was 40 years ago so when the chance comes along to shoot a doomsday stomping rifle I am not tempted.