I also fall under the very large hands group. As a young man I considered going into OB but decided out of kindness to all future female patients my oversized mitts would not be tolerated well. Hand strength is very much something I have always enjoyed. Until my body started wearing out extra strength came in handy, now it just makes the PT easier.
Never had a problem with a trigger guard hitting my middle finger. That might be because I have large, strong hands, long fingers or just dumb luck. Happy either way. On guns people complain about hitting their fingers I look at the shape of the trigger guard. More than a few people complain about guns with very flat rear trigger guards. Very much like a brick wall. Always figured the trigger guard was too close to the middle finger and to upright for the finger to have much room.
