Keith
I have not found a problem when hunting, with the bullets striking at the top of the bead. It doesn't matter how large the bead may be, it's not covering the strike spot.
In use, I align the sights (well, as best I can!), and raise them up the animal until the top of the bead reaches the spot I need to hit. Then press the trigger.
It's worked so far.
BTW If y'all have read "The Art of Still Hunting" by T.S. van Dyke, published, I believe, in the 1880's, he recommends a flat bar rear sight made of black rubber. The old first hand accounts like this are always a great source of inspiration. Too many good methods have been lost to time.