Yep, they were listed as resident at:
333 Genesee St, Buffalo, Erie, New York

Interestingly, the wife, Barbara shows as being born in Prussia for the 1880 census. His name is listed as Frank H Escherich in the 1880 tract. 17 people are at that address with 5 surnames. Occupations are doctor, gunsmith (our guy), clerk, apprentice machinist, and special detective for the other residents. All the women are listed as keeping house. From the listing, it does not appear to be a rooming house, which is what I have usually found with gunsmith's of that era.

Pete