The question is dangerous in that broad generalizations are required to answer it. I believe the best answer is the gun would, if in proper repair, digest loads which replicate the loads it was originally built to shoot. So first, is the gun in proper repair? Then what was it's original intended load? Last, how do you make sure you are getting ammo that approximates it's original load standards. If you are shooting anything over the original load (pressure, velocity and weight of ejecta all considered) the answer is you are not proceeding cautiously.