Deep seated primers are often the cause of a misfire, but in the case of the Comp Ones it is another cuplrit. The shell rim seats too deep in the chamber rim cut on many guns. The profile of the shell rim looks different, when you compare to other loads I shoot, all of which shoot fine in those guns.
With the barrels off the gun and held vertically you can drop a load in the chamber, then with a depth mike measure the distance from the face of the barrels to the primer. When you do this with different loads you can easily see the ones, if any, that sit deeper in the rim cut.
Does it seem to be just one particular loading that is causing the problems, because the Fiocchis I've used have always worked fine, AIR?
SRH