Let's say you have a 12 gauge gun and want to shoot a heavy charge with a 600 grain hard cast slug. (Assume recoil isn't an issue, although I imagine recoil will be stout). 150 grains would roughly equal 2500 ft lbs. Would 200 grains equal 300 ft pounds? Does anyone know what the approximate pressure would be?

It seems like 150 grains in a 72 caliber with an equivalent weight bullet would manage more energy than a 150 grain charge in a .45 or .50 caliber rifle. Is this due to the different burning dynamics of black powder? (Does the wider cross sectional area allow more of the powder to burn?)