I have shot and killed a lot of Hogs in Texas. Most all with a rifle and a couple with my .44 Mag. If the Hog weighs more than 200lbs and it is a frontal shot I would not take it with buckshot because of the frontal shield. I have shot large hogs with a 30-06 thru the chest area and seen them run like they were not hit for 50yds.
I try to shoot them if possible behind the ear in the vertibre if it is a large hog. Smaller ones of course are not critical.
Be careful however,because hogs are shockingly fast when frightened and a person can not outrun them.