The Royal Canadian has or had a fly fishing deal. The pricing was something like $8,000.
http://www.royalcanadianpacific.com/flyfishing.html

The Rovos was or is a hefty $22,000
http://www.gssafaris.com/destinations/luxury-african-hunting-train-safari.php

It would be cheaper to rent an RV and pay a driver....

Pete