doc06,
There are many here who shoot old damascus barreled guns on a regular basis. There are others who would never shoot them. The problem is that they passed proof 90 - 100+ years ago.
It is impossible to tell what has been done to them. Unless you are willing to pay to have the gun reproofed today.
I recently sent a set of barrels to Mike Orlen for some work. These are fluid steel barrels from about 1950. Mike emailed me and later we talked on the phone.
He found some rather thin spots just ahead of the fore end. In fact they measured at only 0.020 thickness. Whether this was a dent that was badly repaired or some one with getting aggressive with a hone is unclear.
We both decided the gun should be retired.
Each gun has to be treated as unique. The barrels should be measured for thickness. The action and lock up should be checked.
Some guns should simply not be fired with any ammo at any pressure. It is a judgement call, that should be made with as much information as possible about the gun in question.
Damascus presents a unique situation. It was constructed out of a billet of various steels. It was welded at every stage.
This was a great improvement over the old rolled steel barrels that would burst at the seam. However, every one of those welds presents the possibility of corrosion over time if the barrels were not cared for properly.

If you are sure of the gun in question, look to start around 5,000 psi.
For some old black powder loads take a look at:
http://www.tbullock.com/bpsg.htmlPeter