Maybe for a while, then likely it will get loose. Note the case of the Stevens 44, these were made for black powder cartridges up to .38-55 but when revived in the 1930s as the 417 Stevens in .22 Hornet, notwithstanding the smaller head size, they couldn't hold it for long and the calibre was discontinued.

But if there is anyone out there who has a Ballard hot varminter that has had thousands of rounds through it let me hear a different opinon.