Be careful not to overcompress your charge. When I was first starting out, I figured that like scotch, if a little is good a lot is better :>) I made up a plunger so I could really compress the powder in a 32-40; the result was that they shot 1 foot low at 100 yds because the powder now burned like a great big briquet. If you feel that you need more oomph then go to 3F powder.
Black powder is unlike smokeless in the sense that more or less you fill the case and don't particularly have to worry about pressures as long as you do not use 4F powder which is only for priming flintlocks.

cheers Doug